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Genetics of eye colours in different rural populations on the Silk Road

Sheila Ulivi1, Massimo Mezzavilla, Paolo Gasparini

  • 1Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.

European Journal of Human Genetics : EJHG
|March 15, 2013
PubMed

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Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.