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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

How important is transfusion avoidance in 2013?

Iain C Macdougall1, Gregorio T Obrador

  • 1Department of Renal Medicine, King's College Hospital, London SE5 9RS, UK. iain.macdougall@nhs.net

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|March 15, 2013
PubMed
Summary
This summary is machine-generated.

Erythropoietin therapy revolutionized anemia management in kidney failure patients, reducing blood transfusions and improving transplant outcomes. This review questions if transfusion avoidance remains critical given recent safety concerns.

Keywords:
ESA therapyHLA sensitizationanaemiatransfusionstransplantation

Related Experiment Videos

Last Updated: May 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Nephrology
  • Hematology
  • Immunology

Background:

  • Anemia in end-stage renal failure (ESRF) was historically managed with frequent blood transfusions.
  • Recombinant erythropoietin (epoetin) introduction in the late 1980s enabled sustained anemia correction, reducing transfusions and iron overload.
  • Transfusion avoidance improved kidney transplant access and outcomes by minimizing HLA sensitization.

Purpose of the Study:

  • To reassess the importance of transfusion avoidance in 2013 for ESRF patients.
  • To evaluate current concerns regarding HLA sensitization in the context of evolving anemia management.

Main Methods:

  • Review of literature on anemia management in ESRF.
  • Analysis of trends in blood transfusion use and erythropoiesis-stimulating agent (ESA) safety.
  • Assessment of HLA sensitization data in relation to transfusion practices.

Main Results:

  • Erythropoietin therapy significantly decreased red blood cell transfusions and associated iron overload.
  • Reduced transfusions led to decreased HLA sensitization, improving kidney transplant success.
  • Recent safety concerns with ESAs may be leading to an increase in blood transfusions.

Conclusions:

  • Transfusion avoidance remains crucial for optimizing outcomes in ESRF patients, particularly regarding kidney transplantation.
  • The re-emergence of transfusion use necessitates a re-evaluation of strategies to mitigate risks like HLA sensitization.