Methicillin-resistant Staphylococcus pseudintermedius infection in a bone marrow transplant recipient

Area of Science:

• Veterinary Infectious Diseases
• Human Infectious Diseases
• Antimicrobial Resistance

Background:

• Staphylococcus pseudintermedius is a common veterinary pathogen.
• Human infections caused by S. pseudintermedius are infrequently documented.
• Coagulase-positive staphylococci represent a significant group of bacterial pathogens.

Observation:

• A case of graft-versus-host disease (GVHD) is presented.
• A wound infection associated with GVHD was observed.
• The causative agent was identified as Staphylococcus pseudintermedius.

Findings:

• The identified S. pseudintermedius strain was multidrug-resistant.
• This strain exhibited resistance to multiple classes of antibiotics.
• The infection occurred in the context of a complex medical condition (GVHD).

Implications:

• This case underscores the potential for zoonotic transmission of S. pseudintermedius.
• Highlights the importance of recognizing S. pseudintermedius as a potential human pathogen.
• Emphasizes the clinical challenge posed by multidrug-resistant veterinary pathogens in human infections.