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Updated: Feb 8, 2026
06:51
Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
Published on: September 5, 2025
656
[Does permanent cardiac stimulation through B - type natriuretic peptide secretion influence the basic parameters of
Janusz Sielski1, Agnieszka Janion-Sadowska
1Swietokrzyskie Centrum Kardiologii w Kielcach, Oddzial Kardiologii. jsielski7@interia.pl
Summary
Pacemaker implantation can alter kidney function, with B-type natriuretic peptide (BNP) levels increasing in the DDD/R pacing mode. This suggests BNP may help assess both renal and cardiac health post-implantation.
Area of Science:
- Cardiology
- Nephrology
- Biomedical Engineering
Background:
- Artificial pacing via pacemakers can induce aberrant waveforms.
- Aberrant waveforms are linked to increased secretion of natriuretic peptides, primarily B-type natriuretic peptide (BNP).
Purpose of the Study:
- To investigate the impact of artificial pacing on renal function.
- To determine if increased BNP secretion during pacing modifies renal function.
Main Methods:
- 117 patients with pacemakers (AAI/R, DDD/R, VVWl/R) and 48 controls were studied.
- Serum BNP, creatinine, and urea levels were measured before and at 3 and 6 months post-pacemaker implantation.
Main Results:
- BNP levels significantly increased at 3 and 6 months in the DDD/R pacing group.
- Urea levels rose in the AAI/R group, while creatinine increased in DDD/R and VVWl/R groups.
- BNP levels remained stable in AAI/R and VVWl/R pacing modes.
Conclusions:
- Pacemaker implantation affects renal function, with varying impacts based on pacing mode.
- BNP levels increase specifically in the DDD/R pacing mode.
- BNP may serve as a valuable biomarker for assessing renal and cardiac function after pacemaker implantation.
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