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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Association analysis between MDR1 gene polymorphisms and risk of hepatocellular carcinoma in Chinese population
Daokun Yang1, Fujun Zhou, Xinwei Wang
1Department of Infectious Diseases, The First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan province, People's Republic of China. daokunyang@sina.com
Abstract:
The objective of this study was to evaluate the association between MDR1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. Genomic DNA of 1431 subjects was extracted from peripheral blood and genotyping was performed using the created restriction site-polymerase chain reaction (CRS-PCR). We found that the c.1465C > T single nucleotide polymorphisms (SNP) increased HCC risk in all genetic models (p < 0.05) and the allele-T of c.1465C > T may contribute to the risk of HCC. No significantly increased HCC risk was detected in c.159G > T SNP. Our data indicated that the genetic variants of MDR1 gene may be a valuable molecular marker for HCC.
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