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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: May 13, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Using PET/CT imaging to characterize 18 F-fluorodeoxyglucose utilization in fish.

Z S Browning1, A A Wilkes, D S Mackenzie

  • 1Comparative Medicine Program, Texas A&M University, College Station, TX, USA.

Journal of Fish Diseases
|March 16, 2013
PubMed
Summary
This summary is machine-generated.

Fish show significant glucose uptake in key organs, making them promising alternatives for cancer research. This study validates their use in advanced imaging techniques like positron emission tomography/computed tomography (PET/CT).

Keywords:
18 F-fluorodeoxyglucosecomputed tomographyfishpositron emission tomography

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Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
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Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules

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Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

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Last Updated: May 13, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
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Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

Area of Science:

  • Comparative oncology
  • Animal models in biomedical research

Background:

  • Mammalian models are standard in cancer research, but alternatives are sought.
  • Combined positron emission tomography/computed tomography (PET/CT) is a powerful imaging tool, largely unutilized in fish.
  • Fish offer potential as alternative research models due to physiological similarities.

Purpose of the Study:

  • To assess the viability of fish as alternative animal models for cancer research using FDG-PET/CT.
  • To analyze glucose uptake similarities between fish and humans in key organs.
  • To evaluate the potential of fish in oncogenesis, metabolism, and environmental carcinogenesis studies.

Main Methods:

  • Utilized combined ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging in multiple fish species.
  • Quantified glucose uptake in various organs, focusing on brain, kidneys, and liver.
  • Compared standard uptake values (SUVs) of glucose in fish organs to those of humans, mice, and dogs.

Main Results:

  • Demonstrated rapid and quantifiable glucose uptake in fish, particularly in the brain, kidneys, and liver.
  • Observed that standard uptake values for glucose in fish organs were more comparable to humans than to mice or dogs.
  • Successfully applied advanced PET/CT imaging technology to fish models.

Conclusions:

  • Fish exhibit significant glucose uptake patterns similar to humans, supporting their use as alternative models in biomedical research.
  • FDG-PET/CT is a viable technique for studying fish, enabling detailed anatomical and metabolic imaging.
  • Fish represent a promising alternative to mammalian models for cancer, metabolism, and environmental carcinogenesis research.