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Updated: May 13, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Impaired coronary microvascular function and its association with disease duration and inflammation in patients with

Hakan Gullu1, Mustafa Caliskan, Recep Dursun

  • 1Cardiology Department, Adana Teaching and Medical Research Center, Baskent University, Adana, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|March 16, 2013
PubMed

Insights

Coronary flow reserve (CFR) is reduced in psoriasis patients, correlating with disease severity and inflammation. This study highlights potential cardiovascular implications of psoriasis.

Area of Science:

  • Cardiology
  • Dermatology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory disease with known associations to cardiovascular comorbidities.
  • Inflammation in psoriasis may impact systemic vascular function.

Purpose of the Study:

  • To investigate coronary flow reserve (CFR) in patients with psoriasis compared to healthy controls.
  • To explore the relationship between CFR and clinical markers of psoriasis severity and inflammation.

Main Methods:

  • Echocardiography was performed on 36 patients with psoriasis and 56 healthy volunteers.
  • Measurements included transmitral inflow velocities, left ventricular myocardial velocities, and coronary flow reserve (CFR) via Doppler of the LAD.
  • Coronary diastolic peak flow velocity (DPFV) was assessed at baseline and hyperemia.

Main Results:

  • Patients with psoriasis exhibited significantly lower hyperemic DPFV and CFR compared to controls (2.19 ± 0.39 vs. 2.60 ± 0.31, P < 0.0001).
  • Baseline DPFV was higher in the psoriasis group, but hyperemic DPFV was lower.
  • CFR showed a significant inverse correlation with disease duration, Psoriasis Area and Severity Index (PASI) score, and high-sensitivity C-reactive protein (hsCRP).

Conclusions:

  • Coronary flow reserve is diminished in patients with psoriasis.
  • Reduced CFR in psoriasis is associated with disease duration, severity (PASI), and systemic inflammation (hsCRP).
  • These findings suggest impaired coronary microvascular function in psoriasis, potentially contributing to cardiovascular risk.
Abstract

Keywords:
coronary flow reserveechocardiographypsoriasis

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