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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Principles of Drug Action01:24

Principles of Drug Action

Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...

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Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
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Published on: June 28, 2013

How to design multi-target drugs.

Tamás Korcsmáros1, Máté S Szalay, Csaba Böde

  • 1Semmelweis University, Department of Medical Chemistry, PO Box 260, H-1444 Budapest 8, Hungary and Predinet Ltd., Dongo Street 8, H-1149 Budapest, Hungary +36 1 266 2755 ; +36 1 266 6550 ; csermely@predinet.com.

Expert Opinion on Drug Discovery
|March 16, 2013
PubMed
Summary

Multi-target drugs offer a promising avenue for drug discovery, expanding potential targets and reducing side effects compared to traditional single-target approaches. This review explores network strategies for identifying effective multi-target drug candidates.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Systems Biology

Background:

  • Despite advances in drug design and screening, novel single-target drugs have stagnated.
  • Multi-target drugs offer a paradigm shift by engaging multiple targets, leading to network-dependent effects.

Purpose of the Study:

  • To review recent advancements in multi-target drug discovery.
  • To compare network attack strategies for identifying drug targets.
  • To propose methods for selecting target sets for multi-target drugs.

Main Methods:

  • Review of current literature on multi-target drug design.
  • Comparative analysis of network-based drug targeting strategies.
  • Exploration of methods for target set identification.

Main Results:

  • Multi-target drugs expand the druggable proteome and increase potential drug targets.
  • Low-affinity binding in multi-target drugs enhances druggability.
  • Novel classes of multi-target drugs exhibit reduced side effects and toxicity.

Conclusions:

  • Multi-target drug design presents a viable strategy to overcome limitations of single-target approaches.
  • Network-centric strategies are crucial for identifying effective multi-target drug candidates.
  • Further development of target-set selection methods is needed for novel drug classes.