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Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Related Experiment Video

Updated: May 13, 2026

Evaluation of Antioxidant and Anthelmintic Properties of Tithonia diversifolia Extracts Against Gastrointestinal Nematode Eggs Using In Vitro Assays

Evaluation of Antioxidant and Anthelmintic Properties of Tithonia diversifolia Extracts Against Gastrointestinal Nematode Eggs Using In Vitro Assays

Published on: August 1, 2025

Target identification and validation for anthelmintic discovery.

Warwick N Grant¹, Carolyn A Behm

¹La Trobe University, Genetics Department, Bundoora, Vic 3085, Australia +61 3 9479 5067 ; +61 3 9479 5067 ; w.grant@latrobe.edu.au.

Expert Opinion on Drug Discovery

|March 16, 2013

Summary

This summary is machine-generated.

New anthelmintic drug discovery requires novel molecular targets. RNA interference in nematodes offers a powerful tool for identifying and validating these targets, advancing drug development pipelines.

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Last Updated: May 13, 2026

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Area of Science:

Parasitology
Drug Discovery
Genomics

Background:

Current anthelmintics were discovered via empirical screening.
Modern drug discovery relies on genetic and genomic target identification.
Existing anthelmintics target only three molecular pathways, necessitating new targets.

Purpose of the Study:

To outline an idealized drug discovery pipeline for nematode anthelmintics.
To critically discuss methods for identifying and validating new drug targets.

Main Methods:

Review of current anthelmintic discovery approaches.
Discussion of genetic, bioinformatic, and genomic target identification.
Emphasis on RNA interference for target validation in nematodes and Caenorhabditis elegans.

Main Results:

Existing anthelmintic targets are limited.
Functional genomics in helminths is underdeveloped.
RNA interference is the most viable technology for target discovery and validation.

Conclusions:

Novel molecular targets are urgently needed for anthelmintic development.
RNA interference technology is crucial for advancing anthelmintic drug discovery pipelines.
A structured approach is required to identify and validate new targets.