Related Experiment Video

Updated: May 13, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Left ventricular dyssynchrony predicts clinical response to CRT - a long-term follow-up single-center prospective

Christian Prinz1, Roman Lehmann, Maria Schwarz

  • 1Department of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.

Echocardiography (Mount Kisco, N.Y.)
|March 16, 2013
PubMed

Insights

Left ventricular dyssynchrony (LVD) assessed by echocardiography predicts long-term response to cardiac resynchronization therapy (CRT) in chronic heart failure patients. This method also indicates improved reverse left ventricular remodeling.

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Echocardiography

Background:

  • Lack of consensus on defining clinical response to cardiac resynchronization therapy (CRT) in chronic heart failure (CHF) with systolic left ventricular (LV) dysfunction.
  • Need for objective markers to predict long-term CRT efficacy.

Purpose of the Study:

  • To evaluate echocardiography's predictive value for objective exercise capacity improvement during long-term CRT follow-up.
  • To determine if baseline echocardiographic parameters predict clinical response to CRT.

Main Methods:

  • Echocardiography and spiroergometry performed at baseline and follow-up.
  • Left ventricular dyssynchrony (LVD) defined by tissue Doppler imaging (TDI) as intra-LV delay ≥40 msec.
  • Clinical response to CRT defined as >10% increase in peakVO2 or maximal workload.

Main Results:

  • Mean follow-up was 69 months; 59% of 238 patients were clinical responders.
  • Baseline LVD was more frequent in responders (64%) than non-responders (42%) (P=0.004).
  • LVD at baseline independently predicted long-term clinical response (P<0.001) and was associated with improved LV ejection fraction and reduced LV end-diastolic diameter.

Conclusions:

  • Baseline LVD, assessed via echocardiography, predicts long-term clinical response to CRT.
  • Echocardiographic assessment of LVD is linked to more significant reverse LV remodeling post-CRT.
Abstract

Keywords:
cardiac resynchronization therapy (CRT)clinical responseelectromechanical delay (EMD)long-term follow-upventricular dyssynchrony

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...