Related Experiment Video
Updated: May 13, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Pharmacogenetics: where are we with respect to personalized medicine?
Joel A Lefferts1, Claudine L Bartels, Gregory J Tsongalis
1Dartmouth Medical School, Department of Pathology, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA +1 603 650 5498 ; +1 603 650 4845 ; gregory.j.tsongalis@hitchcock.org.
Abstract:
The application of genetic testing to predict how well or how poorly an individual will respond to a therapeutic drug is beginning to make its way into the clinical laboratory. As this testing begins to unfold in the clinical setting, there is a necessary paradigm change that must occur for the laboratory and for the healthcare provider in order for this to be successful. New molecular-based technologies are commercially available to perform this testing on a routine basis and several established examples of pharmacogenetic tests are currently being performed. Several national organizations are now working on practice guidelines for the incorporation of this testing into a clinical setting. This manuscript provides an overview of where we are with respect to pharmacogenetic testing.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Pharmacogenetics and Pharmacogenomics: Overview
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Metabolism: Overview
Principles of Pharmacogenetics: Types of Genetic Variants
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase