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Paraneoplastic hypertrophic osteopathy in 30 dogs
S S Withers1, E G Johnson2, W T N Culp2
1William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Veterinary and Comparative Oncology
|March 16, 2013
Summary
Paraneoplastic hypertrophic osteopathy (pHO) in dogs commonly presents with leg swelling, ocular issues, lameness, and lethargy. This study details these clinical signs and common blood abnormalities in affected canine cancer patients.
Area of Science:
- Veterinary Medicine
- Oncology
- Internal Medicine
Background:
- Paraneoplastic hypertrophic osteopathy (pHO) is a recognized condition in canine and human cancer patients.
- While the pathology of pHO is understood in dogs, comprehensive clinical presentation data is lacking.
Purpose of the Study:
- To provide a detailed clinical picture of paraneoplastic hypertrophic osteopathy (pHO) in dogs.
- To identify common presenting complaints and physical examination findings associated with pHO.
- To document haematological and serum biochemical abnormalities in dogs with pHO.
Main Methods:
- Retrospective identification of 30 dogs diagnosed with pHO.
- Data collection on presenting complaints and physical examination findings at diagnosis.
- Review of available haematological and serum biochemical test results.
Main Results:
- The most frequent clinical signs observed were leg swelling, ocular discharge/episcleral injection, lameness, and lethargy.
- Common haematological abnormalities included anemia and neutrophilia.
- Elevated alkaline phosphatase was a frequent serum biochemical abnormality.
Conclusions:
- This study offers a more comprehensive clinical description of pHO in dogs.
- The findings support previously reported haematological, biochemical, and physical examination abnormalities in individual case reports.
- The data aids in recognizing and diagnosing pHO in canine cancer patients.
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