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Updated: May 13, 2026
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Inflammatory markers and their association with post stroke cognitive decline.
Kaavya Narasimhalu1,2, Jasinda Lee3, Yi Lin Leong3
1Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Summary
Inflammation impacts cognitive function in stroke survivors. Higher interleukin 8 is linked to initial cognitive impairment, while elevated interleukin 12 predicts later cognitive decline after ischemic stroke.
Area of Science:
- Neurology
- Immunology
- Neuroscience
Background:
- Population studies link inflammation and cognitive impairment.
- Limited research exists on this association in ischemic stroke patients.
Purpose of the Study:
- To investigate the relationship between inflammatory markers and cognitive impairment in ischemic stroke patients.
- To identify specific inflammatory markers associated with baseline and subsequent cognitive status.
Main Methods:
- Longitudinal study of 243 ischemic stroke patients with up to five years of annual neuropsychological assessments.
- Assayed inflammatory markers including C-reactive protein, IL-1β, IL-6, IL-8, IL-10, IL-12, and TNF-α.
- Used logistic regression to analyze associations between inflammatory markers and cognitive status/decline.
Main Results:
- Interleukin 8 (IL-8) levels were independently associated with baseline cognitive impairment (OR 1.23).
- Interleukin 12 (IL-12) levels were independent predictors of subsequent cognitive decline (OR 25.02).
- Age, education, ethnicity, and stroke subtype also influenced baseline cognition; age, gender, and recurrent strokes predicted decline.
Conclusions:
- Elevated serum interleukin 8 is associated with cognitive impairment at baseline in ischemic stroke patients.
- Increased serum interleukin 12 is linked to subsequent cognitive decline following ischemic stroke.
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