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Study of mature cells in human myeloid malignancies by premature chromosome condensation
1Service d'Hématologie Clinique, Pavillon Marcel-Bérard 1F, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
Abstract:
The premature chromosome condensation technique allows cytogenetic studies (chromosomes scoring or karyotyping after banding) of mature non cycling cells. In conjunction with cell fractionation, it appears a powerful tool to study spontaneous or therapy-induced maturation of cells of acute myelogenous leukemia or myelodysplastic syndrome patients. It is useful for determining the involvement of multiple lineages in hematopoietic diseases.