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Infectious endocarditis in children
Insights
Infectious endocarditis (IE) in children is a severe condition, often linked to congenital heart disease. Poor prognosis factors include young age, Staphylococcus aureus, and prosthetic material.
Area of Science:
- Pediatrics
- Infectious Diseases
- Cardiology
Background:
- Infectious endocarditis (IE) remains a significant pediatric health concern.
- Understanding current epidemiological and clinical characteristics is crucial for effective management.
Purpose of the Study:
- To analyze the contemporary features of infectious endocarditis in pediatric patients.
- To identify etiological agents, predisposing factors, and outcomes in children with IE.
Main Methods:
- Retrospective study of 23 pediatric cases (under 15 years) of IE.
- Data collected from Hospital Ramón y Cajal, Madrid, between 1977 and 1985.
- Analysis of patient demographics, underlying conditions, causative organisms, and treatment outcomes.
Main Results:
- High incidence observed (1.3 cases per 1000 admitted children).
- Congenital heart disease was the predominant predisposing factor (20/23 cases).
- Streptococcus viridans and Staphylococcus aureus were the most common pathogens; mortality rate was 26%.
Conclusions:
- Infectious endocarditis in children is a severe illness with a notable mortality rate.
- Younger age (<2 years), Staphylococcus aureus infection, and prosthetic material are associated with a poor prognosis.
- Congenital heart disease significantly increases the risk of IE in pediatric populations.
Abstract:
With the object of analyzing current characteristics of infectious endocarditis (IE) in children, we carried out a retrospective study of 23 cases of IE in children under 15 years of age seen at the Hospital Ramón y Cajal in Madrid (Spain) between 1977 and 1985. The incidence was high (1.3 cases per 1000 children admitted). The male/female ratio was 2:1. Eight patients were under 2 years of age and 15 over 2 years, the majority being adolescents. The two groups presented marked etiological and prognostic differences. Congenital heart disease was the predisposing factor in 20 of the 23 cases. Streptococcus viridans (nine cases) and Staphylococcus aureus (eight cases) were the most frequent organisms. Fourteen cases were on a native valve and nine were secondary (seven of these on prosthetic patches). In spite of advances in therapy, IE continues to be a severe illness: the mortality rate in our series was 26%. Factors associated with a poor prognosis were: age less than 2 years, Staphylococcus aureus as the causative agent, and the presence of prosthetic material.
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