Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperostosis frontalis interna, acromegaly and hyperprolactinaemia.

J D Fulton1, J Shand, D Ritchie

  • 1Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, UK.

Postgraduate Medical Journal
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>KRAS</i> internal tandem duplications and alternative driver variants in <i>BRAF</i> Val600Glu negative hairy cell leukemia.

Leukemia & lymphoma·2026
Same author

On Guarana.

Medical examiner (Philadelphia, Pa.)·2023
Same author

Genetic characterization of the zoonotic parasite <i>Ancylostoma caninum</i> in the central and eastern United States.

Journal of helminthology·2023
Same author

The impact of having a carer on adult health and social care utilisation across five settings of care: A matched cohort study.

Health policy (Amsterdam, Netherlands)·2023
Same author

Evaluation of the impact of the European Code against Cancer on awareness and attitudes towards cancer prevention at the population and health promoters' levels.

Cancer epidemiology·2021
Same author

Autologous stem cell transplantation for untreated transformed indolent B-cell lymphoma in first remission: an international, multi-centre propensity-score-matched study.

British journal of haematology·2020

Hyperostosis frontalis interna (HFI) is more common in acromegaly patients, especially those with hyperprolactinaemia. This association warrants further investigation in acromegaly management.

Area of Science:

  • Endocrinology
  • Radiology
  • Medical Imaging

Background:

  • Hyperostosis frontalis interna (HFI) is a condition characterized by thickening of the inner table of the frontal bone.
  • Acromegaly is a hormonal disorder caused by excessive growth hormone production.
  • Hyperprolactinaemia is a condition of elevated prolactin levels in the blood.

Purpose of the Study:

  • To investigate the association between hyperostosis frontalis interna (HFI) and acromegaly.
  • To determine if hyperprolactinaemia influences the prevalence of HFI in acromegalic patients.

Main Methods:

  • Skull X-rays of 36 acromegalic patients (19 with hyperprolactinaemia) were compared to 36 age-sex matched controls.
  • Intra- and interobserver variability for HFI assessment was evaluated.

Related Experiment Videos

  • Subgroup analyses were performed comparing acromegalics and acromegalics with hyperprolactinaemia to controls.

    • Main Results:

    • HFI was significantly more prevalent in the acromegalic cohort compared to controls (P = 0.0002).
    • This association was observed in both male and female acromegalic patients.
    • Acromegalic patients with hyperprolactinaemia showed a higher HFI prevalence than controls (P = 0.0001).
    • HFI severity correlated with age in both sexes and with disease duration in females.

    Conclusions:

    • A strong association exists between HFI and acromegaly, particularly when hyperprolactinaemia is present.
    • The findings suggest HFI may have symptomatic significance in acromegaly.
    • Confirmation or refutation of HFI is recommended for all acromegaly patients.