Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-mediated immunity in the uremic rat.

A M Munster, A G Leary, R A Wilson

    International Archives of Allergy and Applied Immunology
    |January 1, 1975
    PubMed
    Summary

    Uremia significantly suppresses cell-mediated immunity in rats, as shown by the popliteal node assay. This immunosuppression correlates with the severity of kidney disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A changing landscape: Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006-2015.

    Thrombosis research·2019
    Same author

    Dominant antibody responses to Fucalpha1-3GalNAc and Fucalpha1-2Fucalpha1-3GlcNAc containing carbohydrate epitopes in Pan troglodytes vaccinated and infected with Schistosoma mansoni.

    Experimental parasitology·2004
    Same author

    Cis-acting elements, CArG-, E-, CCAAT- and TATA-boxes may be involved in sexually regulated gene transcription in Schistosoma mansoni.

    Memorias do Instituto Oswaldo Cruz·2002
    Same author

    The study of T-cell activation in peripheral blood and spleen of hepatosplenic patients suggests an exchange of cells between these two compartments in advanced human Schistosomiasis mansoni infection.

    Scandinavian journal of immunology·2002
    Same author

    After 10 years and 1903 inguinal hernias, what is the outcome for the laparoscopic repair?

    Surgical endoscopy·2002
    Same author

    The M. tuberculosis antigen 85 complex and mycolyltransferase activity.

    Letters in applied microbiology·2002

    Area of Science:

    • Immunology
    • Nephrology
    • Cellular Immunity

    Background:

    • Cell-mediated immunity is crucial for immune responses.
    • Uremia, or kidney failure, can impact immune function.
    • The popliteal node assay is a validated method for assessing immune responses.

    Purpose of the Study:

    • To investigate the impact of uremia on cell-mediated immunity in rats.
    • To quantify immunosuppression in uremic conditions using the popliteal node assay.

    Main Methods:

    • Utilized the popliteal node assay in inbred rats.
    • Assessed spleen cells from both normal and uremic Lewis rats.
    • Cultured normal spleen cells in uremic serum.

    Main Results:

    • Uremic rat spleen cells showed significant immunosuppression.
    • Normal cells cultured in uremic serum also exhibited immunosuppression.
    • The degree of immunosuppression was directly proportional to the severity of uremia.

    Conclusions:

    • Uremia induces significant immunosuppression, impairing cell-mediated immunity.
    • The popliteal node assay effectively measures this uremia-induced immune deficit.
    • Kidney disease severity directly correlates with the level of immunosuppression.

    Related Experiment Videos