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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Updated: May 13, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
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Biggest challenges in bioinformatics.

Jonathan C Fuller1, Pierre Khoueiry, Holger Dinkel

  • 1Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.

EMBO Reports
|March 16, 2013
PubMed
Summary
This summary is machine-generated.

The Heidelberg Unseminars in Bioinformatics (HUB) convened experts to identify key challenges in the field. Discussions focused on advancing bioinformatics through collaborative problem-solving and innovative strategies.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Life Sciences

Background:

  • The Heidelberg Unseminars in Bioinformatics (HUB) is an event series fostering discussion on critical issues in the field.
  • The third HUB meeting focused on identifying and addressing the most significant challenges in modern bioinformatics.

Framework:

  • A 'World Café' style event facilitated interactive discussions among participants.
  • The event encouraged open dialogue and collaborative problem-solving.

Implementation:

  • Approximately 40 bioinformaticians from academic and industrial sectors participated.
  • The discussions were held at Heidelberg University, Germany, on October 18, 2012.

Implications:

  • Identifying major challenges is crucial for guiding future research and development in bioinformatics.
  • Cross-sector collaboration can accelerate solutions to complex biological data analysis problems.