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Updated: May 13, 2026
06:39
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Disseminated tuberculosis masquerading primary myelodysplastic syndrome
Syahrul Sazliyana Shaharir1, Nor Rafeah Tumian, Andrea Ban Yu Lin
1Department of Internal Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia. sazliyana@hotmail.com
Journal of Infection in Developing Countries
|March 16, 2013
Summary
Tuberculosis can mimic other diseases, causing blood count abnormalities. This case highlights how cytogenetic studies are crucial for distinguishing tuberculosis-related marrow changes from primary myelodysplastic syndrome.
Area of Science:
- Hematology
- Infectious Diseases
- Oncology
Background:
- Tuberculosis (TB) is a complex infection known for its diverse clinical presentations.
- Hematologic abnormalities are common in disseminated TB, particularly with bone marrow involvement.
- Distinguishing reactive marrow changes from primary hematologic disorders can be challenging.
Observation:
- A 61-year-old male presented with right empyema and pancytopenia.
- Disseminated tuberculosis was diagnosed based on marrow granulomas and pleural fluid acid-fast bacilli.
- Initial marrow findings of trilineage dysplasia were attributed to reactive changes from infection.
Findings:
- The patient showed poor response to anti-tuberculosis treatment.
- A repeat cytogenetic study revealed trisomy 8.
- This unmasked an underlying primary myelodysplastic syndrome.
Implications:
- This case underscores the varied hematologic manifestations of tuberculosis.
- Cytogenetic analysis is vital for differentiating secondary myelodysplastic changes from primary myelodysplastic syndrome.
- Early and accurate diagnosis is essential for appropriate patient management.
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