Advances in click chemistry for single-chain nanoparticle construction
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Updated: May 13, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Ana Sanchez-Sanchez1, Irma Pérez-Baena, José A Pomposo
1Centro de Fisica de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizabal 5, E-20018 San Sebastian, Spain. ana_sanchez@ehu.es
Abstract:
Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.

