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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Updated: May 13, 2026

Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain
06:31

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Published on: October 8, 2021

Exploring neurogenesis in crustaceans.

Carol Ann Paul1, Erin M Goergen, Barbara S Beltz

  • 1Biology Department, Wellesley College, Wellesley, MA 02481.

Journal of Undergraduate Neuroscience Education : JUNE : a Publication of FUN, Faculty for Undergraduate Neuroscience
|March 16, 2013
PubMed
Summary
This summary is machine-generated.

This study details a lab for students to investigate how environmental factors influence neurogenesis, the creation of new neurons. Using crayfish, the experiment quantifies neuronal cell division, offering insights into learning, memory, and neurological disease research.

Keywords:
BrdUbromodeoxyuridinecrustaceanneurogenesisneuroscience

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neurogenesis, the formation of new neurons, is crucial for learning, memory, and neurological disease research.
  • Environmental factors are known to influence neurogenesis, but experimental models for students are limited.
  • Invertebrate models, like crayfish, offer advantages for studying neurogenesis due to simpler nervous systems and identifiable neurons.

Purpose of the Study:

  • To design and implement a student laboratory exercise to experimentally investigate the regulation of neurogenesis by environmental factors.
  • To provide a hands-on learning experience for students to explore neurogenesis in a model organism.
  • To demonstrate the conservation of neurogenesis mechanisms across species, from invertebrates to mammals.

Main Methods:

  • Utilized the crayfish model system for studying neurogenesis.
  • Employed fluorescently-labeled BrdU (bromodeoxyuridine) to identify and quantify neuronal cell division.
  • Employed conventional or confocal microscopy for visualizing and quantifying labeled neurons.

Main Results:

  • The lab successfully allowed students to experimentally examine how environmental factors alter the rate of neurogenesis.
  • Student-designed experiments provided insights into the regulation of neurogenesis.
  • The methodology proved effective for quantifying neuronal cell division in crayfish.

Conclusions:

  • The designed lab is an effective tool for teaching students about neurogenesis and its regulation.
  • Invertebrate models like crayfish are valuable for studying neurogenesis in an accessible educational setting.
  • This approach facilitates discovery-oriented learning and can be expanded to explore various factors influencing neurogenesis.