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Calcium channel blockers: effect on morphine-induced hypermotility
M I Martin1, I Lizasoain, J C Leza
1Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Psychopharmacology
|January 1, 1990
Summary
Calcium channel blockers, nifedipine and diltiazem, significantly reduced morphine-induced hypermotility in mice. These drugs did not affect amphetamine-induced hypermotility, suggesting a specific interaction with morphine's effects.
Area of Science:
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Acute morphine administration induces hypermotility and calcium depletion in brain regions.
- Calcium channel blockers are known to enhance morphine analgesia and reduce withdrawal symptoms.
Purpose of the Study:
- To evaluate the effect of calcium channel blockers (nifedipine and diltiazem) on morphine- and amphetamine-induced hypermotility in mice.
- To investigate the potential interaction between calcium channel blockers and stimulant-induced behavioral effects.
Main Methods:
- Mice were treated with morphine or amphetamine.
- Nifedipine and diltiazem were administered to assess their impact on locomotor activity.
- Locomotor activity was quantified using photocell motility meters.
Main Results:
- Nifedipine and diltiazem did not significantly alter motility in control or amphetamine-treated mice.
- Both nifedipine and diltiazem significantly reduced hypermotility in morphine-treated mice.
- The observed reduction in hypermotility suggests a specific interaction with morphine's effects.
Conclusions:
- Calcium channel blockers specifically counteract morphine-induced hypermotility in mice.
- The precise mechanism underlying this interaction remains to be elucidated.
- Findings suggest a role for calcium channels in mediating morphine-induced behavioral stimulation.