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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 13, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

"IM iD"eally treating multiple myeloma.

Martha Q Lacy1

  • 1Mayo Clinic College of Medicine, USA.

Blood
|March 16, 2013
PubMed
Summary
This summary is machine-generated.

Two trials investigate pomalidomide and dexamethasone for relapsed and refractory multiple myeloma (MM). These studies offer insights into treatment options for patients with advanced multiple myeloma.

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Last Updated: May 13, 2026

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10:04

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Area of Science:

  • Hematology
  • Oncology
  • Clinical Trials

Background:

  • Multiple myeloma (MM) is a cancer of plasma cells.
  • Relapsed and refractory MM presents significant treatment challenges.

Purpose of the Study:

  • To evaluate the efficacy of pomalidomide and dexamethasone in patients with relapsed and refractory multiple myeloma (MM).

Main Methods:

  • Two distinct clinical trials were conducted.
  • Patients received treatment with pomalidomide and dexamethasone.

Main Results:

  • The studies present findings from two separate trials.
  • Results pertain to patients with relapsed and refractory multiple myeloma.

Conclusions:

  • Pomalidomide and dexamethasone are being investigated as treatment options for MM.
  • Further analysis of these trials will inform clinical practice.