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Updated: May 13, 2026

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

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Developing a project-oriented introduction to neuroscience lab at hope college.

Leah A Chase¹, Christopher C Barney

¹Biology Department, Hope College, Holland, MI 49423; ; Chemistry Department, Hope College, Holland, Michigan 49423.

Journal of Undergraduate Neuroscience Education : JUNE : a Publication of FUN, Faculty for Undergraduate Neuroscience

|March 16, 2013

Summary

This neuroscience lab project investigating gonadal hormone effects on rat brain and behavior improved students' scientific inquiry and writing skills. Students gained practical experience in data analysis and interpreting results, enhancing their understanding of neuroendocrinology.

Keywords:

NMDA receptor phosphorylation hippocampal slice introductory neuroscience course lab project liberal arts college long-term potentiation ovariectomy self assessment of learning gains sex behavior sex steroids sexually dimorphic nucleus spatial learning

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Area of Science:

Neuroscience
Endocrinology
Behavioral Biology

Background:

Neuroscience courses often lack hands-on research experience.
Understanding gonadal hormone effects on the brain is crucial in neuroscience.

Purpose of the Study:

To assess the impact of an extended laboratory project on student learning in an introductory neuroscience course.
To evaluate the project's effectiveness in developing students' scientific skills and understanding of neuroendocrinology.

Main Methods:

Students conducted ovariectomies and hormone implants (sham, estradiol, testosterone) in rats.
Five experiments were performed: sexual behavior, spatial learning (Morris Water Maze), sexually dimorphic nucleus size, NMDA receptor phosphorylation, and long-term potentiation.
Data were analyzed statistically, and results were summarized in journal-style reports.

Main Results:

The lab project generated statistically significant data.
Students reported improved abilities in formulating scientific questions, understanding complex interdisciplinary problems, summarizing scientific literature, and writing reports using data.

Conclusions:

An extended lab project effectively engages students in neuroscience topics.
This project enhances students' practical skills and fosters the development of neuroscientist habits.