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[The effect of ascorbic acid administration on its levels in the brain tissue in intact and hypoxic 18-day-old rats]
1Fyziologický ústav fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Sbornik Lekarsky
|March 1, 1990
Abstract:
A single dose of ascorbic acid, 1 mg/g of body weight by the i.p. route, caused a marked increase of its content in five areas of the brain in 18-day-old laboratory rats, as compared with intact animals. Acute hypoxia at 9000 m mitigated this increase. Conversely a combination of chronic intermittent hypoxia and ascorbic acid administration led in all investigated areas of the brain to a mild but insignificant rise of values except for the vermis cerebelli, where a significant rise at the 5% level of significance occurred.