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09:26
Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
Evaluation of colloidal solid dispersions: physiochemical considerations and in vitro release profile
Vaibhav I Patel1, Rutesh H Dave
1Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, 75 Dekalb Avenue, HS Building 605, Brooklyn, NY 11201, USA.
AAPS Pharmscitech
|March 16, 2013
Summary
A new method enhances drug dissolution using sulfathiazole-polyvinylpyrrolidone solid dispersion with porous silicon dioxide. This ternary system significantly increases the dissolution rate of poorly soluble drugs.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Poorly soluble drugs present significant formulation challenges.
- Solid dispersions and amorphous approaches are key strategies to enhance drug solubility and bioavailability.
- Carrier materials play a crucial role in stabilizing amorphous forms and improving drug release.
Purpose of the Study:
- To develop a novel adsorption method for creating sulfathiazole-polyvinylpyrrolidone (Plasdone® K-29/32) solid dispersions on porous silicon dioxide (Syloid® 244FP).
- To investigate the impact of ternary systems on the physicochemical properties and in vitro dissolution of sulfathiazole.
- To optimize the ratio of components in the ternary system for maximum dissolution enhancement.
Main Methods:
- Preparation of ternary systems (sulfathiazole-Plasdone® K-29/32-Syloid® 244FP) using a novel adsorption method.
- Characterization using Modulated Differential Scanning Calorimetry (MDSC), X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR).
- In vitro dissolution studies conducted using USP apparatus II at 75 rpm in various media.
Main Results:
- XRD and MDSC confirmed the loss of crystallinity of sulfathiazole in all prepared ternary systems.
- The optimum ratio (1:2:2) of sulfathiazole-Plasdone® K-29/32-Syloid® 244FP demonstrated a three-fold increase in dissolution rate.
- Porous silicon dioxide effectively dispersed the drug-carrier complex, leading to enhanced dissolution.
Conclusions:
- The developed adsorption method successfully created amorphous solid dispersions with improved drug release.
- Ternary systems incorporating porous silicon dioxide offer a promising approach to overcome solubility issues in pharmaceutical formulations.
- This strategy significantly enhances the dissolution rate of poorly soluble drugs like sulfathiazole.
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