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Updated: May 13, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
G protein-coupled estrogen receptor 1 expression in human vocal fold
Daquan Wu1, Jack J Jiang, Rui Fang
1Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.
Objectives/Hypothesis:
Besides the classical sexual receptors, the expression of a recently clarified transmembrane G protein-coupled receptor (GPR30) has not been reported in the vocal fold so far. We aimed to study whether GPR30 is expressed in the human vocal fold.
Study Design:
Experimental study using pathologic human vocal fold tissues.
Methods:
Reverse-transcription polymerase chain reaction and immunohistochemistry were used to detect the GPR30 expression in a total of 83 vocal fold samples.
Results:
A total of 66% of the specimens tested were GPR30 mRNA positive, and 54% of the sections were revealed to be GPR30 immunostaining positive in the plasma membrane as well as the nucleus in the epithelial cells.
Conclusions:
The GPR30 expression both in mRNA and protein level could be detected in the human vocal fold.
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