Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AUTHOR'S REPLY.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2017
Same author

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON MENOPAUSE-2017 UPDATE.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2017
Same author

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME - PART 2.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2015
Same author

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2015
Same author

COMMENTARY ON THE ROLE OF INSULIN SENSITIZERS ON CARDIOVASCULAR RISK FACTORS IN POLYCYSTIC OVARIAN SYNDROME: A META-ANALYSIS.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2015
Same author

In response.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2014
Same journal

When Rosai-Dorfman meets autoimmunity.

Internal and emergency medicine·2026
Same journal

Hypocholesterolemia as a predictor of mortality in infective endocarditis.

Internal and emergency medicine·2026
Same journal

Correction: Diagnostic accuracy and clinical impact of internist-performed point-of-care ultrasound in atrial fibrillation: a multicenter study.

Internal and emergency medicine·2026
Same journal

Managing emergency department overcrowding: analysis through a dynamic simulation model of the impact of organizational variables on emergency department processes.

Internal and emergency medicine·2026
Same journal

Gunshot-induced carotid artery injury: exploring other determined aetiologies of stroke.

Internal and emergency medicine·2026
Same journal

Machine learning phenotypes and heterogeneous albumin effects in cirrhotic AKI: a causal inference study.

Internal and emergency medicine·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

Cardiovascular and metabolic risks associated with PCOS.

Rhoda H Cobin1

  • 1The Mount Sinai School of Medicine, New York, NY, USA. rhcobin@gmail.com

Internal and Emergency Medicine
|March 16, 2013
PubMed
Summary
This summary is machine-generated.

Polycystic ovary syndrome (PCOS) is linked to higher risks of type 2 diabetes and heart disease. Identifying women with PCOS is crucial for managing these serious cardiometabolic risks.

More Related Videos

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Related Experiment Videos

Last Updated: May 13, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Cardiovascular Health

Background:

  • Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder among women of reproductive age.
  • PCOS is frequently associated with insulin resistance, increasing the risk of various metabolic and cardiovascular complications.
  • Women with PCOS exhibit higher incidences of type 2 diabetes, hyperlipidemia, and vascular disease.

Purpose of the Study:

  • To investigate the association between Polycystic Ovary Syndrome (PCOS) and cardiometabolic disorders.
  • To highlight the impact of different diagnostic criteria for PCOS on the assessment of insulin resistance and associated risks.
  • To emphasize the importance of identifying women with PCOS for timely intervention and prevention of severe health consequences.

Main Methods:

  • Review of epidemiologic studies and clinical trials.
  • Analysis of diagnostic criteria for PCOS used in Europe and the United States.
  • Assessment of cardiometabolic risk markers in women with PCOS.

Main Results:

  • PCOS is associated with increased frequency of type 2 diabetes, hyperlipidemia, and cardiac risk markers.
  • The definition of PCOS influences the perceived role of insulin resistance and the risk of cardiometabolic disorders.
  • Clinical and epidemiological data underscore the elevated risk of vascular and clinical disease events in women with PCOS.

Conclusions:

  • Early identification of women with PCOS is essential for risk stratification.
  • Management strategies should focus on mitigating cardiometabolic risks associated with PCOS.
  • Understanding the spectrum of PCOS and its link to insulin resistance is key to preventing serious health outcomes.