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[Tenoxicam and renal function. Short-term and long-term prospective studies].
J L Giovannoni1, H Ott, A de Torrenté
1Département de médecine et Service de rhumatologie, Hôpital, La Chaux-de-Fonds.
Schweizerische Medizinische Wochenschrift
|May 26, 1990
Summary
Tenoxicam use in high-risk patients may impair kidney function, necessitating monitoring. In lower-risk patients, tenoxicam shows no significant renal risk compared to other NSAIDs.
Area of Science:
- Nephrology
- Pharmacology
- Rheumatology
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) can affect renal function.
- Tenoxicam is an NSAID used for inflammatory conditions.
Purpose of the Study:
- To prospectively evaluate the influence of tenoxicam on renal function in different patient populations.
- To compare renal risks of tenoxicam with other NSAIDs.
Main Methods:
- Prospective study in two groups: high renal risk (n=10) and rheumatology outpatients (n=56).
- Administered 20 mg tenoxicam daily.
- Measured glomerular filtration rate (GFR) using Cr51 EDTA and plasma creatinine.
Main Results:
- High-risk patients showed a significant 13% decrease in GFR (p<0.01).
- Rheumatology outpatients had no significant change in plasma creatinine, except one with pre-existing impairment.
- Tenoxicam demonstrated comparable renal safety to other NSAIDs in non-high-risk individuals.
Conclusions:
- Tenoxicam use requires renal function monitoring in high-risk patients.
- In non-high-risk populations, tenoxicam appears to have a similar renal safety profile to other NSAIDs.