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The clinical utility of genetic risk variants in type 2 diabetes
Jeff Gulcher1, Kari Stefansson
1Decode Genetics, Inc., Sturlugata 8, 101 Reykjavik, Iceland jeffrey.gulcher@decode.is.
Background:
Type 2 diabetes is one of the first success stories in the application of genome-wide linkage and association studies to find genetic variants contributing to its risk.
Objective:
Are the genetic markers found so far useful in predicting which individuals are more likely to develop type 2 diabetes? Can they find which patients with prediabetes are more likely to convert to type 2 diabetes and therefore may benefit the most from lifestyle or pharmacologic prevention strategies?
Methods:
The literature pertaining to the discovery and replications of genes contributing to type 2 diabetes was focused on.
Results/Conclusion:
Substantial risk for type 2 diabetes is represented by the top 8 genes, including TCF7L2, and in certain circumstances may be useful for prevention strategies targeted to those with highest risk.
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