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Rheumatoid arthritis diagnosis with antimutated citrullinated vimentin ELISA by Orgentec Diagnostika
Zoltán Szekanecz1, Gabriella Lakos
1University of Debrecen, Medical and Health Science Centre, Institute of Medicine, Department of Rheumatology, 22 Moricz street, Debrecen, H-4032, Hungary +36 52 314 091 ; +36 52 414 489 ; szekanecz@iiibel.dote.hu.
Background:
There is a need for highly sensitive and specific laboratory tests for the early diagnosis of rheumatoid arthritis (RA). Anticitrullinated protein/peptide antibodies are produced in the sera of RA patients.
Objective:
To assess and discuss the diagnostic value of Orgentec antimutated citrullinated vimentin (anti-MCV) ELISA and to compare this diagnostic to commercially available anticyclic citrullinated peptide (anti-CCP) tests.
Methods:
The evaluation is based on our recently published study on the comparison of anti-MCV and anti-CCP2 tests, as well as on published studies.
Results/Conclusion:
In established RA, the anti-MCV ELISA exerts a specificity comparable with anti-CCP2. Numerous recent studies suggest that anti-MCV may have higher sensitivity, however there are also some publications stating the opposite. In early RA, anti-MCV may be a better predictor of disease activity and radiological progression than anti-CCP tests.
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