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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 13, 2026

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
11:49

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Drug target identification and quantitative proteomics.

Tao He1, Yeoun Jin Kim, Jenny L Heidbrink

  • 1Protein Therapeutics, Celera Genomics, Rockville, MD 20850, USA. tao.he@celera.com.

Expert Opinion on Drug Discovery
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Proteomic analysis offers new ways to find drug targets by studying protein details. This review covers quantitative proteomics and mass spectrometry for faster target discovery, especially for antibody therapies.

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Related Experiment Videos

Last Updated: May 13, 2026

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
11:49

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification
09:04

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification

Published on: August 17, 2015

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Area of Science:

  • Proteomics
  • Mass Spectrometry
  • Therapeutic Drug Discovery

Background:

  • Emerging proteomic technologies offer insights into protein expression, modifications, and interactions.
  • These insights are crucial for identifying novel therapeutic drug targets for unmet medical needs.

Purpose of the Study:

  • To summarize current quantitative proteomic concepts and mass spectrometric technologies.
  • To illustrate the application of proteomics in target identification and validation, particularly for monoclonal antibody therapies.
  • To discuss current challenges and future directions in proteomic studies for target and biomarker discovery.

Main Methods:

  • Review of quantitative proteomic concepts.
  • Summary of mass spectrometric technologies.
  • Examples of target identification and validation strategies.

Main Results:

  • Quantitative proteomics and mass spectrometry accelerate drug target discovery.
  • Proteomics has been successfully applied in identifying targets for monoclonal antibody therapies.
  • The review highlights key strategies and technologies in the field.

Conclusions:

  • Proteomic analysis is a powerful tool for identifying therapeutic targets.
  • Further advancements in proteomics will enhance the discovery of biomarkers and drug targets.
  • Addressing current bottlenecks is essential for maximizing the potential of proteomic studies.