Non-invasive assessment of vulnerable plaque

Sudden cardiac death or unheralded acute coronary syndromes are common initial manifestations of coronary atherosclerosis and most such events occur at sites of non-flow limiting coronary atherosclerosis.

Non-invasive detection of high-risk plaques might provide a means to improve risk stratification in primary and secondary prevention settings.

This review is focused on the potential of multidetector computed tomography coronary angiography (MDCT-CA) to provide the opportunity to identify different aspects of plaque vulnerability throughout the coronary tree in an accurate, fast, safe and non-invasive manner.

Coronary artery calcium scoring, on top of established risk stratification, could potentially be a cost-effective strategy for primary prevention. MDCT-CA allows a non-invasive evaluation of several features commonly seen in vulnerable plaques and has demonstrated an independent prognostic value on a patient basis. The value of the technique itself might result, potentially, in a better estimation of the relative risk of an invidual plaque to rupture.