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Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

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Related Experiment Video

Updated: May 13, 2026

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

Atherosclerosis imaging in drug development.

Stephen J Nicholls1, Srinivasa Kalidindi, Keon-Woong Moon

  • 1Cleveland Clinic, Department of Cardiovascular Medicine, Mail Code JJ-65, 9500 Euclid Avenue, Cleveland OH, 44195, USA +1 216 444 2678 ; +1 216 445 5769 ; nichols1@ccf.org.

Expert Opinion on Drug Discovery
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Developing new antiatherosclerotic agents is challenging due to lengthy clinical trials. Arterial wall imaging offers a promising approach for evaluating novel therapies targeting atherosclerotic cardiovascular disease.

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Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis
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Last Updated: May 13, 2026

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis
08:13

Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis

Published on: March 22, 2016

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Medical Imaging

Background:

  • Established therapies complicate the evaluation of new antiatherosclerosis drugs.
  • Extensive clinical trials with large patient numbers and long follow-up periods hinder drug development.
  • Atherosclerotic cardiovascular disease remains a leading cause of mortality worldwide.

Purpose of the Study:

  • To address the challenges in assessing experimental antiatherosclerotic agents.
  • To explore the utility of advanced imaging techniques in clinical trials.
  • To facilitate the development of novel therapies for atherosclerotic cardiovascular disease.

Main Methods:

  • Utilizing technological advances in arterial wall imaging.
  • Implementing clinical trial designs that incorporate serial imaging of the arterial wall.
  • Evaluating the impact of therapies on the natural progression of atherosclerosis.

Main Results:

  • Serial arterial wall imaging provides an efficient method for assessing antiatherosclerotic agents.
  • This imaging approach can potentially reduce the duration and size of clinical trials.
  • The use of imaging in trials is becoming increasingly prevalent in drug development.

Conclusions:

  • Technological advancements in arterial wall imaging offer a viable solution to the challenges in developing new antiatherosclerosis treatments.
  • Serial imaging facilitates a more efficient assessment of therapeutic efficacy.
  • This methodology supports the advancement of treatments for atherosclerotic cardiovascular disease.