Towards microfluidic technology-based MALDI-MS platforms for drug discovery: a review.

Area of Science:

• Analytical Chemistry
• Biotechnology
• Pharmaceutical Sciences

Background:

• Microfluidic methods are increasingly applied across scientific disciplines.
• Microfluidic technology is predicted to streamline drug discovery processes, from target identification to lead optimization.
• The vast parameter space in combinatorial screening presents a significant challenge that microfluidics can address.

Purpose of the Study:

• To assess the current integration of microfluidic systems with matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) for drug discovery applications.
• To evaluate the proximity of these integrated technologies to routine use in pharmaceutical research.

Main Methods:

• A comprehensive literature review was conducted.
• The review focused on the latest applications of microfluidic technology within the context of MALDI-MS and drug discovery.

Main Results:

• Microfluidic-based approaches have been identified for multiple stages of the drug discovery pipeline.
• Current applications of these technologies in drug discovery are predominantly in developmental phases.

Conclusions:

• Integrated microfluidic-MALDI-MS systems offer potential for advancing drug discovery.
• Further development is needed to realize the full capabilities of these technologies for routine pharmaceutical research.
• Future applications may involve enhanced efficiency and scope in drug screening and development.