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Related Experiment Video

Updated: May 13, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Molecular testing in transfusion medicine.

Franz F Wagner¹

¹Red Cross Blood Service NSTOB, Eldagsener Str. 38, D-31832 Springe, Germany +49 5041 772172 ; +49 5041 772421 ; fwagner@bsd-nstob.de.

Expert Opinion on Medical Diagnostics

|March 19, 2013

Summary

Molecular blood group prediction is revolutionizing transfusion medicine by enabling mass donor genotyping. These advanced molecular methods complement traditional testing, improving blood supply for specific patient needs.

Area of Science:

Transfusion Medicine
Molecular Diagnostics
Genetics

Background:

Molecular blood group prediction, including mass donor genotyping, is increasingly standard in transfusion medicine.
This review focuses on transfusion-related applications of molecular antigen prediction for red blood cells.

Purpose of the Study:

To provide an overview of molecular testing for blood group antigen prediction in transfusion medicine.
To explain the principles and challenges associated with molecular blood group testing.
To guide the selection of appropriate molecular methods for specific transfusion applications.

Main Methods:

Review of transfusion-related applications of molecular red blood cell antigen prediction.
Literature search using terms 'molecular testing transfusion' and related articles.

Related Experiment Videos

Last Updated: May 13, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Focus on author's personal experience in the field.

Main Results:

Readers will grasp the fundamentals and challenges of molecular blood group antigen prediction.
An overview of current molecular testing methods is presented.
Guidance on method suitability for specific applications is provided.

Conclusions:

Molecular methods currently supplement serologic antigen determination for specific diagnostic needs.
Mass-scale molecular antigen prediction for blood donors is enhancing blood supply for certain patient populations.