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Updated: May 13, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

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Published on: August 9, 2019

Aptamers as imaging agents.

Sonia Da Rocha Gomes¹, Laurent Azéma, Michèle Allard

¹Novaptech, 2 rue Robert Escarpit, 33607 Pessac, France.

Expert Opinion on Medical Diagnostics

|March 19, 2013

Summary

This summary is machine-generated.

Aptamer-based probes offer high-affinity targeting for diagnostics and therapeutics. These oligonucleotide probes are valuable for tumor imaging due to their binding and clearance properties.

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Area of Science:

Biotechnology
Molecular Biology
Nanotechnology

Background:

Aptamers are structured oligonucleotides with high affinity and specificity for diverse targets.
Recent advances in imaging have spurred the development of aptamer-based probes for diagnostics.
Aptamers are emerging as key targeting molecules in advanced imaging applications.

Purpose of the Study:

To review aptamer-based imaging probes for ex vivo and in vivo applications.
To discuss the advantages and challenges associated with aptamer probe development.
To highlight the potential of aptamers in diagnostic and therapeutic applications.

Main Methods:

Aptamers are selected using systematic evolution of ligands by exponential enrichment (SELEX).
Oligonucleotides can be modified to enhance nuclease resistance and in vivo bioavailability.
Conjugation with labels (colorimetric, fluorescent, radiolabeled) enables detection of cancer-related antigens.

Main Results:

The review covers various aptamer-based imaging probes for both ex vivo and in vivo use.
Advantages of aptamer probes, including specificity and affinity, are presented.
Challenges in aptamer probe development, such as stability and delivery, are discussed.

Conclusions:

Aptamers demonstrate a broad range of applications from diagnostics to therapeutics.
Their specific binding, tumor retention, and clearance characteristics make them effective tumor imaging probes.