Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human-centred design thinking as a co-creation process: A commentary.

Preventive medicine·2025
Same author

Utilization of direct oral anticoagulants in a Saudi tertiary hospital: a retrospective cohort study.

European review for medical and pharmacological sciences·2023
Same author

Physical characterization and wound healing properties of Zamzam water.

Brazilian journal of biology = Revista brasleira de biologia·2022
Same author

Gingival Thickness and Outcome of Periodontal Plastic Surgery Procedures: A Meta-regression Analysis.

JDR clinical and translational research·2020
Same author

[Angiokeratoma].

Annales de dermatologie et de venereologie·2020
Same author

Modified Procedure to Inoculate Micro-ID.

Journal of food protection·2019
Same journal

Authors' Reply "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Neutrophils From Aged Individuals Release NETs to Impair Oral Wound Healing Through NLRP3 Activation.

Oral diseases·2026
Same journal

Comment on "Multimodal Deep Learning-Based Screening of Degenerative Temporomandibular Joint Disease Using 2D Radiography: A Cost-Effective and Low-Radiation Approach".

Oral diseases·2026
Same journal

Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches.

Oral diseases·2026
Same journal

Comment on "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Atypical Whitish Gingival Plaque.

Oral diseases·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Celiac disease.

E Rivera1, A Assiri, S Guandalini

  • 1Section of Gastroenterology, Hepatology and Nutrition Department of Pediatrics, University of Chicago, IL, USA.

Oral Diseases
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Celiac disease, a common gluten intolerance affecting 1% of the population, presents with diverse gastrointestinal and extra-intestinal symptoms. Early diagnosis via anti-tissue transglutaminase antibodies and biopsy, followed by a gluten-free diet, is key for symptom management.

Keywords:
medicinepublic health

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Related Experiment Videos

Last Updated: May 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Celiac disease is the most prevalent genetically-induced food intolerance globally, affecting approximately 1% of the general population.
  • It is an enteropathy triggered by gluten ingestion in susceptible individuals, manifesting with a broad spectrum of clinical presentations at any age.

Purpose of the Study:

  • To outline the diverse clinical manifestations of celiac disease, encompassing both gastrointestinal and extra-intestinal symptoms.
  • To highlight the diagnostic pathway and current management strategies for celiac disease.

Main Methods:

  • Review of clinical signs and symptoms associated with celiac disease.
  • Description of diagnostic methods including serological screening (anti-tissue transglutaminase antibodies) and intestinal biopsy.
  • Discussion of treatment protocols, primarily a strict gluten-free diet.

Main Results:

  • Celiac disease presents with varied gastrointestinal issues (diarrhea, pain, weight loss) and increasingly recognized extra-intestinal manifestations (dermatitis herpetiformis, anemia, osteoporosis, infertility, oral issues).
  • Diagnostic confirmation relies on detecting anti-tissue transglutaminase autoantibodies followed by intestinal biopsy.
  • A strict gluten-free diet typically leads to significant symptom improvement.

Conclusions:

  • Celiac disease requires a high index of suspicion due to its wide-ranging symptoms.
  • Effective management hinges on accurate diagnosis and adherence to a gluten-free diet.
  • Ongoing research aims to develop alternative treatments for non-responsive celiac disease patients.