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Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...

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Related Experiment Video

Updated: May 13, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Modeling the interaction of DNA with alternating fields.

A E Bergues-Pupo1, J M Bergues, F Falo

  • 1Departamento de Física, Universidad de Oriente, 90500 Santiago de Cuba, Cuba.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|March 19, 2013
PubMed
Summary

A terahertz field influences DNA thermal properties and melting transitions. This study explores how external fields modify DNA

Area of Science:

  • Molecular Biophysics
  • Computational Biology
  • Biophysics

Background:

  • DNA thermal properties are crucial for biological functions.
  • Understanding DNA dynamics under external stimuli is essential.
  • The Peyrard-Bishop-Dauxois model is a standard for DNA dynamics.

Purpose of the Study:

  • To investigate the effect of terahertz fields on DNA thermal properties.
  • To analyze modifications in DNA melting transitions and bubble formation.
  • To explore the influence of solvent interactions on DNA behavior under terahertz irradiation.

Main Methods:

  • Utilizing the Peyrard-Bishop-Dauxois model.
  • Incorporating a solvent interaction term.
  • Applying a sinusoidal driven force to represent the terahertz field.

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Studying DNA Looping by Single-Molecule FRET
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Last Updated: May 13, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Studying DNA Looping by Single-Molecule FRET
11:27

Studying DNA Looping by Single-Molecule FRET

Published on: June 28, 2014

  • Analyzing changes in melting transition and bubble formation dynamics.

    • Main Results:

    • Terahertz fields significantly alter DNA thermal properties.
    • Specific field and system parameters can modify DNA melting transitions.
    • Bubble formation in DNA molecules is affected by terahertz irradiation.
    • Solvent interactions play a role in modulating these effects.

    Conclusions:

    • Terahertz fields offer a novel way to control DNA thermal behavior.
    • The findings provide insights into DNA-molecule interactions.
    • This research opens avenues for novel applications in molecular electronics and drug design.