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A case-control study on the association between bladder cancer and prior bladder calculus
Shiu-Dong Chung1, Ming-Chieh Tsai, Ching-Chun Lin
1Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.
BMC Cancer
|March 19, 2013
Summary
Bladder calculus, or bladder stones, significantly increases the risk of developing bladder cancer (BC). This finding suggests bladder stone history is a key factor for BC screening and prevention strategies.
Area of Science:
- Urology
- Oncology
- Epidemiology
Background:
- Bladder calculus is linked to chronic bladder irritation and inflammation.
- Inflammation is a known factor in carcinogenesis, but the stone-cancer link is unclear.
- This study investigates the association between bladder stones and bladder cancer (BC).
Purpose of the Study:
- To examine the association between bladder cancer (BC) and a prior diagnosis of bladder calculus.
- Utilize a population-based dataset for robust analysis.
Main Methods:
- A case-control study design was employed.
- Included 2,086 incident bladder cancer (BC) cases and 10,430 controls.
- Conditional logistic regression analysis was used to assess the association, adjusting for multiple covariates.
Main Results:
- Bladder calculus was present in 3.4% of BC cases versus 1.1% of controls.
- Individuals with prior bladder calculus had a 3.42-fold increased odds of BC.
- This association remained significant in both males (OR=3.45) and females (OR=3.05) after adjustments.
Conclusions:
- The findings support an association between bladder calculus and an increased risk of bladder cancer (BC).
- This highlights bladder stone history as a potential indicator for targeted bladder cancer screening.
- Further research can clarify the etiological mechanisms linking stones to BC.
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