Related Experiment Video
Updated: May 13, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Giant prolactinoma: case report and review of literature
Masoud Rahmanian1, Hamidreza Aghaei Meybodi, Bagher Larijani
1EMRC (Endocrinology and Metabolism Research Institute), Shariati Hospital,Tehran university of medical science, North Karegar St, Tehran, Iran. mrmohajeri@tums.ac.ir.
Abstract:
"Invasive giant prolactinoma" is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented with central hypogonadism, suppressed adrenal and thyroid function, supra sellar extension, visual field impairment and high prolactin level.The patient was treated with cabergoline, levothyroxin and prednisolone. After 18 months, tumor size markedly reduced, associated with adrenal function and visual field improvement, but central hypogonadism and secondary hypothyroidism persisted.Previous studies showed normalization of thyrotropin secretion after treatment but it remained low in our patient even after 18 months follow up.
Related Concept Videos
Cushing Syndrome II: Pathophysiology
Hormones of the Pituitary Gland
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
Cushing Syndrome I: Introduction
