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Bioactive flavanoids from Glycosmis arborea.

Mohammad Faheem Khan1, Nisha Negi, Rajnikant Sharma

  • 1Department of Chemistry, HNB Garhwal University, Srinagar (Garhwal), Uttarakhand 246174, India. devendra_negi@yahoo.com.

Organic and Medicinal Chemistry Letters
|March 19, 2013
PubMed
Summary

Glycosmis arborea leaves yielded four compounds, including a new flavone C-glycoside. Compound 4 demonstrated significant antimicrobial activity, highlighting its potential medicinal value.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry

Background:

  • Glycosmis, a genus of shrubs found in India, is recognized for its traditional medicinal uses.
  • Glycosmis arborea is a known source of bioactive compounds like alkaloids, terpenoids, coumarins, and flavonoids.

Purpose of the Study:

  • To isolate and characterize chemical constituents from the methanol extract of Glycosmis arborea leaves.
  • To evaluate the isolated compounds and fractions for pest antifeedant and antimicrobial activities.

Main Methods:

  • Methanol extraction of Glycosmis arborea leaves.
  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation of isolated compounds via nuclear magnetic resonance (NMR) spectrometry.
  • Bioactivity screening for pest antifeedant and antimicrobial properties.

Main Results:

  • One novel flavone C-glycoside and three known flavonoids were isolated from the methanol fraction.
  • The structures were confirmed using advanced spectroscopic methods, including NMR.
  • Compound 4, a new flavone C-glycoside, exhibited notable antimicrobial activity.

Conclusions:

  • Four compounds were successfully isolated from Glycosmis arborea leaves.
  • Compound 4 displayed significant antimicrobial effects, suggesting therapeutic potential.
  • Further research into Glycosmis arborea constituents is warranted for drug discovery.