Related Experiment Video

Updated: May 13, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Intestinal lengthening and nutritional outcomes in children with short bowel syndrome

Patrick J Javid1, Sabrina E Sanchez, Simon P Horslen

  • 1Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital and University of Washington School of Medicine, Seattle, WA, USA. patrick.javid@seattlechildrens.org

American Journal of Surgery
|March 19, 2013
PubMed

Insights

Serial transverse enteroplasty (STEP) improved intestinal length and enteral tolerance in children with short bowel syndrome. Most patients were weaned off parenteral nutrition, though gastroschisis may indicate a less favorable outcome.

Area of Science:

  • Pediatric surgery
  • Gastroenterology
  • Intestinal adaptation

Background:

  • Intestinal lengthening is a treatment for pediatric short bowel syndrome.
  • Clinical indications and nutritional outcomes of bowel lengthening are not well-defined.

Purpose of the Study:

  • To evaluate the clinical indications and nutritional outcomes of serial transverse enteroplasty (STEP) in pediatric short bowel syndrome.

Main Methods:

  • Retrospective review of a prospective database of patients who underwent STEP at a single center.

Main Results:

  • STEP increased median small bowel length (84 cm to 103 cm; P=.0001).
  • Parenteral nutrition caloric support decreased significantly after STEP (69% to 0%; P<.01).
  • 80% of patients showed improved enteral tolerance, and 60% achieved enteral autonomy.

Conclusions:

  • A majority of children with short bowel syndrome were successfully weaned off parenteral nutrition after STEP.
  • Gastroschisis may be associated with a less optimal outcome following STEP.
Abstract

More Related Videos

Small Bowel Transplantation In Mice36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...