[Primary lateral sclerosis and lung adenocarcinoma]
L Martinez1, R Lamaze, C Clément-Duchêne
1Service de pneumologie, hôpital de Brabois, CHU de Nancy, 54500 Vandœuvre-lès-Nancy, France. laura.martinez.1@hotmail.fr
Revue Des Maladies Respiratoires
|March 19, 2013
Summary
This case report details primary lateral sclerosis (PLS), a rare motor neurone disease, in a young woman with lung adenocarcinoma. The study highlights the challenging diagnosis and simultaneous progression of both conditions.
Area of Science:
- Neurology
- Oncology
Background:
- Lung cancer is linked to paraneoplastic syndromes, including rare motor neurone diseases.
- Primary lateral sclerosis (PLS) is a progressive upper motor neurone disorder.
Observation:
- A young woman developed PLS symptoms 9 months after a metastatic lung adenocarcinoma diagnosis.
- Symptoms included spastic quadriparesis and bulbar dysfunction without muscle wasting.
- Electromyography confirmed isolated upper motor neurone involvement.
Findings:
- This is the first reported case of PLS in a young woman with lung adenocarcinoma.
- Neurological and oncological conditions progressed concurrently.
- Onconeuronal antibodies were negative, complicating paraneoplastic syndrome confirmation.
Implications:
- This case underscores the importance of considering PLS in lung cancer patients presenting with upper motor neurone dysfunction.
- Further research is needed to clarify the association between PLS and lung adenocarcinoma.
- Early diagnosis and management strategies for this rare paraneoplastic presentation require investigation.
