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Updated: May 13, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Ageing in cystic fibrosis and long-term survival
1Consultant Respiratory Physician/Honorary Senior Lecturer, Department of Cystic Fibrosis, Royal Brompton Hospital/Imperial College, London, UK SW3 6NP. n.simmonds@rbht.nhs.uk
Abstract:
The demographics of cystic fibrosis continue to change with adults outnumbering children in most developed countries. Median predicted survival is now over 40 years and 7.6% are aged >40 years. Patients surviving beyond 40 cover the full spectrum of disease from homozygous F508del to single organ disease. Differences in the characteristics of older patients are recognised, but generally patients diagnosed in adulthood are still at risk of accelerated lung function decline. Improved survival brings new challenges, including a rising rate of CF co-morbidities such as diabetes, in addition to other medical problems such as renal impairment and ototoxicity.
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