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Related Experiment Video

Updated: May 13, 2026

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Intranasal atomized dexmedetomidine for sedation during third molar extraction.

N Nooh¹, S A Sheta, W A Abdullah

¹Department of Oral and Maxillofacial Surgery, King Saudi University, Riyadh, Saudi Arabia. nassernoohomfs@gmail.com

International Journal of Oral and Maxillofacial Surgery

|March 19, 2013

Summary

Intranasal dexmedetomidine effectively sedated patients undergoing third molar extraction. This method proved safe and convenient, offering a viable alternative for dental sedation.

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Last Updated: May 13, 2026

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

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Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow

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Published on: January 13, 2017

Area of Science:

Anesthesiology
Pharmacology

Background:

Sedation is crucial for managing patient anxiety and comfort during dental procedures.
Mandibular third molar removal often requires effective sedation techniques.

Purpose of the Study:

To assess the efficacy and safety of intranasal atomized dexmedetomidine for sedation during mandibular third molar extraction.

Main Methods:

A randomized, crossover study involving 18 patients undergoing third molar removal.
Patients received either intranasal dexmedetomidine (1.5 μg/kg) or placebo (water) in two sessions.
Sedation levels were monitored using the Observer's Assessment of Alertness/Sedation (OAA/S) scale and bispectral index (BIS).

Main Results:

Intranasal dexmedetomidine significantly improved sedation compared to placebo starting at 20-30 minutes post-administration.
Peak sedation effects were observed between 40-50 minutes.
Minor decreases in heart rate and blood pressure were noted, remaining within safe limits (<20% of baseline).

Conclusions:

Intranasal atomized dexmedetomidine is an effective, safe, and convenient sedative for mandibular third molar extraction.
This administration route offers a promising alternative for procedural sedation in dentistry.