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Updated: May 13, 2026
07:59
Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus
Marc Mendelson1, Zunaid Barday, Roland Eastman
1Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa. marc.mendelson@uct.ac.za
Abstract:
Sirolimus, a potent inhibitor of B- and T-cell activation. is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus.
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