Related Experiment Video

Updated: May 13, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

[New evidence in the secondary prevention of thromboembolic disease]

Pablo Javier Marchena Yglesias1

  • 1Departamento de Medicina Interna y Urgencias, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, España. pjmy1@yahoo.es

Medicina Clinica
|March 19, 2013
PubMed

Insights

Recurrent venous thromboembolism affects nearly 40% of patients within 10 years. Indefinite anticoagulation is recommended for high-risk individuals, while others require tailored treatment based on recurrence risk assessment.

Area of Science:

  • Cardiology
  • Hematology

Context:

  • Venous thromboembolism (VTE) recurrence poses a significant long-term risk.
  • Current guidelines recommend varying anticoagulation durations based on risk factors.

Purpose:

  • To review secondary prevention strategies for venous thromboembolism.
  • To discuss risk stratification for VTE recurrence and anticoagulation management.

Summary:

  • Nearly 40% of patients experience VTE recurrence within 10 years.
  • Indefinite anticoagulation with warfarin or acenocoumarol is advised for those with permanent risk factors (excluding cancer patients, who receive LMWH).
  • A 3-month treatment course is suggested for others, followed by individualized reevaluation balancing recurrence and bleeding risks. D-dimer levels, residual thrombosis, and RV dysfunction aid in identifying low-risk patients for discontinuation.

Impact:

  • Highlights the need for personalized anticoagulation management in VTE secondary prevention.
  • Suggests utilizing specific biomarkers and imaging to guide treatment decisions.
  • Anticipates the role of novel oral anticoagulants in future VTE management.

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...