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Colorimetric test-systems for creatinine detection based on composite molecularly imprinted polymer membranes.

T A Sergeyeva1, L A Gorbach, E V Piletska

  • 1Institute of Molecular Biology and Genetics, Kiev, Ukraine. t_sergeyeva@yahoo.co.uk

Analytica Chimica Acta
|March 19, 2013
PubMed
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A novel colorimetric test system efficiently detects creatinine in water samples using molecularly imprinted polymer (MIP) membranes. This innovative method offers a simple, low-cost alternative for creatinine analysis.

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Polymer Chemistry

Background:

  • Creatinine detection is crucial for assessing kidney function and environmental monitoring.
  • Traditional creatinine detection methods can be complex, time-consuming, and expensive.
  • Development of rapid, user-friendly, and cost-effective analytical tools is needed.

Purpose of the Study:

  • To develop an easy-to-use colorimetric test system for efficient creatinine detection in aqueous samples.
  • To create selective molecularly imprinted polymer (MIP) membranes for creatinine recognition.
  • To evaluate the performance and stability of the developed test system.

Main Methods:

  • Fabrication of composite MIP membranes on polyvinylidene fluoride (PVDF) supports via photo-initiated grafting polymerization.

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  • Utilizing functional monomers (e.g., 2-acrylamido-2-methyl-1-propanesulfonic acid, itaconic acid, methacrylic acid) and computational modeling for monomer selection.
  • Selective adsorption of creatinine by MIP membranes followed by colorimetric quantification using picrate reactions.

    • Main Results:

    • The developed MIP membranes demonstrated selective binding and recognition of creatinine.
    • A linear dynamic range of 0.25–2.5 mM and a detection limit of 0.25 mM were achieved.
    • The test system exhibited storage stability of at least 1 year at room temperature.

    Conclusions:

    • The developed colorimetric test system offers a simple, portable, and cost-effective solution for creatinine detection.
    • MIP membranes provide artificial receptor sites for efficient and selective creatinine capture.
    • This technology holds promise for various applications requiring rapid creatinine analysis.