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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: May 13, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Acute burn induced coagulopathy.

P B Sherren1, J Hussey, R Martin

  • 1Department of Pre-hospital Emergency Medicine, Greater Sydney Area Helicopter Emergency Medical Service, Ambulance Service of New South Wales, Australia. petersherren@gmail.com

Burns : Journal of the International Society for Burn Injuries
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Acute burn induced coagulopathy (ABIC) affects nearly 40% of major burn patients. Early diagnosis and treatment of ABIC are crucial, as it independently predicts mortality in burn survivors.

Keywords:
Abbreviated burn severity index (ABSI)Activated partial thromboplastin time (APTT)BurnCoagulopathyProthrombin time (PT)

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Last Updated: May 13, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
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Published on: February 23, 2024

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Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Area of Science:

  • Trauma and Burn Surgery
  • Hematology
  • Critical Care Medicine

Background:

  • Major burns cause endothelial injury and hypoperfusion, similar to acute traumatic coagulopathy.
  • These factors may drive the development of acute burn induced coagulopathy (ABIC).

Purpose of the Study:

  • To investigate the incidence and clinical significance of ABIC in patients with severe burns.
  • To determine if ABIC is associated with mortality.

Main Methods:

  • Analysis of 117 patients with >=30% total body surface area burns admitted over 71 months.
  • Review of electronic patient records for demographics, interventions, and admission investigations to identify ABIC.
  • Statistical analysis to correlate coagulopathy with burn severity, lactate, and mortality.

Main Results:

  • 39.3% of patients presented with coagulopathy on admission.
  • Elevated Prothrombin Time (PT) was the most common finding (71.7%).
  • ABIC was an independent predictor of 28-day mortality (OR 3.42).

Conclusions:

  • Clinically significant ABIC is present in patients with major thermal injuries.
  • Early diagnosis and treatment of ABIC are recommended, especially for patients undergoing burn wound excision.